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Showing 1 to 12 of 3475 entries
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Cyclodextrin-based nanosponges as drug carriers.

Beilstein journal of organic chemistry

Trotta F, Zanetti M, Cavalli R.
PMID: 23243470
Beilstein J Org Chem. 2012;8:2091-9. doi: 10.3762/bjoc.8.235. Epub 2012 Nov 29.

Cyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical...

Gold(I)-catalyzed synthesis of γ-vinylbutyrolactones by intramolecular oxaallylic alkylation with alcohols.

Beilstein journal of organic chemistry

Chiarucci M, Locritani M, Cera G, Bandini M.
PMID: 21977203
Beilstein J Org Chem. 2011;7:1198-204. doi: 10.3762/bjoc.7.139. Epub 2011 Sep 01.

Gold(I)-N-heterocyclic carbene (NHC) complexes proved to be a reliable catalytic system for the direct synthesis of functionalized γ-vinylbutyrolactones by intramolecular oxaallylic alkylation with primary alcohols. Good isolated chemical yields were obtained for a range of malonyl and acetate derivatives....

A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas.

Beilstein journal of organic chemistry

Smith K, El-Hiti GA, Hegazy AS, Kariuki B.
PMID: 21977206
Beilstein J Org Chem. 2011;7:1219-27. doi: 10.3762/bjoc.7.142. Epub 2011 Sep 06.

Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.

Novel carbocationic rearrangements of 1-styrylpropargyl alcohols.

Beilstein journal of organic chemistry

Basmadjian C, Zhang F, Désaubry L.
PMID: 26199656
Beilstein J Org Chem. 2015 Jun 15;11:1017-22. doi: 10.3762/bjoc.11.114. eCollection 2015.

The dehydration and subsequent cyclization reactions of 1-styrylpropargyl alcohols was examined. In the course of these studies, numerous scaffolds were synthesized, including a furan, a cyclopentenone, an acyclic enone and even a naphthalenone. The diversity of these structural motifs...

Synthesis of novel N-cyclopentenyl-lactams using the Aubé reaction.

Beilstein journal of organic chemistry

Shinde MV, Ople RS, Sangtani E, Gonnade R, Reddy DS.
PMID: 26199661
Beilstein J Org Chem. 2015 Jun 23;11:1060-7. doi: 10.3762/bjoc.11.119. eCollection 2015.

A novel and convenient method utilizing the Aubé reaction to access a new class of compounds that are similar to carbocyclic nucleosides is reported. The azido alcohol derived from Vince lactam undergoes the Aubé reaction with various cyclic ketones...

Dimerization reactions of aryl selenophen-2-yl-substituted thiocarbonyl .

Beilstein journal of organic chemistry

McKee ML, Mlostoń G, Urbaniak K, Heimgartner H.
PMID: 28382179
Beilstein J Org Chem. 2017 Mar 03;13:410-416. doi: 10.3762/bjoc.13.44. eCollection 2017.

An intriguing stepwise diradical mechanism of the dimerization of the reactive intermediate (thiocarbonyl

Regioselective palladium-catalyzed ring-opening reactions of C1-substituted oxabicyclo[2,2,1]hepta-2,5-diene-2,3-dicarboxylates.

Beilstein journal of organic chemistry

Edmunds M, Raheem MA, Boutin R, Tait K, Tam W.
PMID: 26977182
Beilstein J Org Chem. 2016 Feb 09;12:239-44. doi: 10.3762/bjoc.12.25. eCollection 2016.

Palladium-catalyzed ring-opening reactions of C1 substituted 7-oxanorbornadiene derivatives with aryl iodides were investigated. The optimal conditions for this reaction were found to be PdCl2(PPh3)2, ZnCl2, Et3N and Zn in THF. Both steric and electronic factors played a role in...

A quadruple cascade protocol for the one-pot synthesis of fully-substituted hexahydroisoindolinones from simple substrates.

Beilstein journal of organic chemistry

Zhang HB, Luo YC, Hu XQ, Liang YM, Xu PF.
PMID: 26977184
Beilstein J Org Chem. 2016 Feb 11;12:253-9. doi: 10.3762/bjoc.12.27. eCollection 2016.

A new and efficient synthetic method to obtain fully-substituted hexahydroisoindolinones was developed by using bifunctional tertiary amine-thioureas as powerful catalysts. As far as we know, there is no efficient synthetic method developed toward fully-substituted hexahydroisoindolinones. The products were obtained...

Cross-metathesis reaction of α- and β-vinyl C-glycosides with alkenes.

Beilstein journal of organic chemistry

Šnajdr I, Parkan K, Hessler F, Kotora M.
PMID: 26425194
Beilstein J Org Chem. 2015 Aug 10;11:1392-7. doi: 10.3762/bjoc.11.150. eCollection 2015.

Cross-metathesis of α- and β-vinyl C-deoxyribosides and α-vinyl C-galactoside with various terminal alkenes under different conditions was studied. The cross-metathesis of the former proceeded with good yields of the corresponding products in ClCH2CH2Cl the latter required the presence of...

Thermal properties of ruthenium alkylidene-polymerized dicyclopentadiene.

Beilstein journal of organic chemistry

Vidavsky Y, Navon Y, Ginzburg Y, Gottlieb M, Lemcoff NG.
PMID: 26425203
Beilstein J Org Chem. 2015 Aug 21;11:1469-74. doi: 10.3762/bjoc.11.159. eCollection 2015.

Differential scanning calorimetry (DSC) analysis of ring opening methatesis polymerization (ROMP) derived polydicyclopentadiene (PDCPD) revealed an unexpected thermal behavior. A recurring exothermic signal can be observed in the DSC analysis after an elapsed time period. This exothermic signal was...

Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-ones and isoquinoline-1,3(2H,4H)-diones.

Beilstein journal of organic chemistry

Qian P, Du B, Jiao W, Mei H, Han J, Pan Y.
PMID: 26977189
Beilstein J Org Chem. 2016 Feb 17;12:301-8. doi: 10.3762/bjoc.12.32. eCollection 2016.

An oxidative reaction for the synthesis of 4-alkyl-substituted dihydroisoquinolin-1(2H)-ones with N-allylbenzamide derivatives as starting materials has been developed. The radical alkylarylation reaction proceeds through a sequence of alkylation and intramolecular cyclization. The substituent on the C-C double bond was...

Optimized methods for preparation of 6(I)-(ω-sulfanyl-alkylene-sulfanyl)-β-cyclodextrin derivatives.

Beilstein journal of organic chemistry

Bednářová E, Hybelbauerová S, Jindřich J.
PMID: 26977195
Beilstein J Org Chem. 2016 Feb 24;12:349-52. doi: 10.3762/bjoc.12.38. eCollection 2016.

A general high-yielding method for the preparation of monosubstituted β-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The thiol group is attached through linkers of different lengths and repeating units (ethylene glycol or methylene)....

Showing 1 to 12 of 3475 entries